"The Prince of Tides" is a gripping narrative about a troubled man who must confront his traumatic past in order to help his twin sister, a poet who has attempted suicide. The protagonist, in the process of aiding his sister's psychiatrist, is forced to delve into their shared history of growing up in a dysfunctional family in South Carolina. The story is a deep exploration of family dynamics, mental health, and the enduring impact of childhood trauma, all set against the backdrop of the Southern United States.

The novel revolves around a precocious twelve-year-old boy named Simons Manigault, who lives with his mother on Edisto Island, South Carolina. As a child prodigy, Simons is pushed by his mother to embrace literature and intellectual pursuits, but he is equally drawn to the local culture and the earthy wisdom of the island's inhabitants. The story captures his coming-of-age experiences, his struggle with his parents' divorce, and his interactions with a cast of colorful characters, including a drifter who becomes an unlikely mentor. Through lyrical prose and a Southern Gothic ambiance, the narrative explores themes of identity, adolescence, and the complex relationship between a boy and the adult world he is entering.

This novel follows the life of Marietta Cook, a tall, resilient African American woman from the Gullah community in South Carolina, as she endures the hardships and complexities of the American South. Through her journey, we witness her strength and determination as she raises her twin sons, contends with racial and social challenges, and strives to maintain her cultural heritage. The narrative, rich with Gullah dialect and traditions, paints a vivid portrait of a woman's struggle for survival and dignity against a backdrop of historical events that shape her community and the nation.