This groundbreaking historical novel follows several generations of an African American family, beginning with Kunta Kinte, a man captured in Gambia in the 18th century and sold into slavery in the United States. Through Kinte and his descendants, the narrative explores the brutal realities of slavery and its aftermath, the struggle for freedom and civil rights, and the perseverance of a family through immense hardship. The story is based on the author's own family history, making it a significant work in the exploration of African American heritage and identity.

Set in 1950s Knoxville, Tennessee, the novel follows the life of a man who has renounced his former existence of privilege to live among society's outcasts on the river. He is an educated man, who has chosen a life of fishing and surviving on the fringes of society. The narrative is filled with his encounters with various characters from the underbelly of the city, including criminals, prostitutes, and other outcasts. Despite his attempts to isolate himself, he finds himself drawn into the problems and tragedies of those around him.

This novel tells the story of a New York editor who is called back to his hometown of Memphis, Tennessee, by his two manipulative older sisters to help them prevent their elderly father from remarrying. As he becomes embroiled in their family drama, he reflects on his upbringing in the South, his father's tyrannical rule over the family, and the impact it had on his life. The narrative explores themes of family, memory, and the passage of time.