Set in 1950s Knoxville, Tennessee, the novel follows the life of a man who has renounced his former existence of privilege to live among society's outcasts on the river. He is an educated man, who has chosen a life of fishing and surviving on the fringes of society. The narrative is filled with his encounters with various characters from the underbelly of the city, including criminals, prostitutes, and other outcasts. Despite his attempts to isolate himself, he finds himself drawn into the problems and tragedies of those around him.

This novel follows the journey of Cora, a young slave on a cotton plantation in Georgia, who escapes and embarks on a journey towards freedom via the Underground Railroad. The book presents a literal version of the historical Underground Railroad, portraying it as a physical network of tunnels and tracks beneath the Southern soil. As Cora travels from state to state, she encounters different worlds and harsh realities, each one illuminating the various forms of oppression Black people faced in America. The narrative is a brutal exploration of America's history of slavery and racism, and a testament to the unyielding spirit of those who fought against it.