The book is a satirical critique of military bureaucracy and the illogical nature of war, set during World War II. The story follows a U.S. Army Air Forces B-25 bombardier stationed in Italy, who is trying to maintain his sanity while fulfilling his service requirements so that he can go home. The novel explores the absurdity of war and military life through the experiences of the protagonist, who discovers that a bureaucratic rule, the "Catch-22", makes it impossible for him to escape his dangerous situation. The more he tries to avoid his military assignments, the deeper he gets sucked into the irrational world of military rule.

The novel follows the life of Billy Pilgrim, a World War II veteran who has become "unstuck in time," experiencing his life events out of order. This includes his experiences as a prisoner of war in Dresden during the Allies' firebombing, his post-war life as a successful optometrist, his abduction by aliens from the planet Tralfamadore, and his eventual death. The book is a critique of war and a demonstration of the destructive nature of time, with a nonlinear narrative that reflects the chaos and unpredictability of life.

"Death Sentence" is a philosophical novella that explores the themes of death, love, and the nature of narrative. The story is divided into two parts, each focusing on a different protagonist who is dealing with the impending death of a loved one. Through their experiences and internal monologues, the novel delves into the complexities of human emotions and the existential dread associated with mortality. The narrative is further complicated by the author's experimental writing style, which challenges traditional storytelling conventions and encourages readers to question their understanding of reality.