The novel is a complex exploration of the intense relationships between teenagers at a competitive performing arts high school in the 1980s. The narrative initially follows the passionate and tumultuous romance between two students, Sarah and David, under the watchful eye of their charismatic drama teacher, Mr. Kingsley. As the story delves into themes of consent, power dynamics, and the manipulation of memory, the reader's understanding of the truth is challenged when the perspective shifts halfway through the book, revealing layers of metafiction and questioning the reliability of narrative and the nature of trust itself.

In the aftermath of the Civil War, an aging itinerant news reader agrees to transport a young girl, who was kidnapped and raised by the Kiowa tribe, back to her biological aunt and uncle. Throughout their perilous journey across the harsh Texas landscape, the pair face myriad dangers and form an unlikely bond. The news reader, with his deep sense of honor and compassion, navigates the challenges of the lawless territory while helping the girl come to terms with her reclaimed identity and the memories of her past. Their shared experiences forge a relationship that transcends the divides of culture and language, reflecting the potential for understanding and healing in a fractured world.

This novel follows the life of Paco Sullivan, the lone survivor of a Vietnam war massacre, as he struggles to reintegrate into civilian life. Haunted by the ghosts of his fallen comrades and burdened by survivor's guilt, Paco grapples with the physical and psychological scars of war while working as a dishwasher in a small Texas town. The narrative explores the harsh realities of post-war trauma and the societal neglect of veterans.

In "Galveston," a once-thriving city is now split between two realities after a magical event known as the Flood. The city is divided between the Mardi Gras-like endless revelry of the supernatural "Fat Tuesday" and the grim existence of "Ash Wednesday," where life is harsh and magic is draining away. The protagonist, a former gambler named Josh Cane, navigates this dual existence, dealing with fantastical creatures, powerful magic, and human desires. As he becomes entangled in the complex politics and struggles of Galveston's inhabitants, he must confront his own demons and make difficult choices that will determine the fate of both realities.

In "Lord of Misrule: The Morganville Vampires", the protagonist and her friends must deal with the chaos that ensues after the town of Morganville becomes a battleground for rival vampire factions. As they navigate the dangerous landscape, they must also deal with personal dilemmas and relationships. The book combines elements of horror, romance, and supernatural fantasy to create a thrilling narrative.

"Everything Begins and Ends at the Kentucky Club" is a collection of seven short stories, all of which are connected by the Kentucky Club, a bar in Ciudad Juárez, Mexico. The stories explore various themes such as love, loss, addiction, and identity, and feature a range of characters, from a young man coming to terms with his sexuality to an older man reflecting on his past relationships. The author uses the backdrop of the U.S.-Mexico border to highlight the complexities and struggles of the characters' lives.