Set in a future Thailand amidst a world ravaged by climate change and depleted resources, the story unfolds in a bustling city where biotech corporations vie for supremacy. The narrative centers around a genetically engineered "New Person," known as the Windup Girl, who is trapped in a life of servitude and exploitation. As the city teeters on the brink of political and environmental collapse, the fates of various characters—including a foreign energy investor, a disgraced geneticist, and a street-smart refugee—intertwine with that of the Windup Girl. Together, they navigate a treacherous landscape of corporate greed, oppressive government, and social upheaval, in a desperate search for survival and redemption in a world where every action has unforeseen consequences.

The 9436th greatest book of all time