This novel tells the story of Dr. Wilbur Larch—saint and obstetrician, founder and director of the orphanage in the town of St. Cloud's, Maine, and a man of rare compassion and an addiction to ether. Dr. Larch loves all his orphans, especially Homer Wells, who is never adopted and becomes his invaluable apprentice. As Homer comes of age, he must leave the only home he's ever known to explore the world outside, a world filled with temptations and moral dilemmas, from the struggle over abortion to the question of what constitutes a family.

The book is a collection of 13 interconnected short stories revolving around Olive Kitteridge, a retired schoolteacher living in a small town in Maine. Olive is a complex character with a prickly exterior but a deep well of emotion and empathy beneath the surface. Through her interactions and relationships with various town residents, the book explores themes of love, loss, aging, and change, painting a rich portrait of a community and its inhabitants.

"Tinkers" is a novel that explores the life of a dying clock repairman who reflects on his life, his father, and his own sons. The narrative moves through time, providing glimpses into the past, from the protagonist's childhood to his own father's experiences as a tinker selling household goods. The story is a poignant examination of family, memory, and death, set against the backdrop of New England's changing seasons.