"The Book of Daniel" is a semi-fictional novel that explores the lives of the Isaacson family, specifically focusing on the children, Daniel and Susan, after their parents, accused of being Communists, are executed. The narrative is a combination of historical fiction and a political commentary, providing a deep exploration of the Red Scare in the United States during the Cold War era. The novel is a critical examination of social, political, and familial dynamics in a time of national fear and paranoia.

This novel tells the story of Dr. Wilbur Larch—saint and obstetrician, founder and director of the orphanage in the town of St. Cloud's, Maine, and a man of rare compassion and an addiction to ether. Dr. Larch loves all his orphans, especially Homer Wells, who is never adopted and becomes his invaluable apprentice. As Homer comes of age, he must leave the only home he's ever known to explore the world outside, a world filled with temptations and moral dilemmas, from the struggle over abortion to the question of what constitutes a family.

The book is a true story about a woman who, after suffering severe physical and emotional abuse as a child, developed sixteen different personalities as a coping mechanism. The narrative follows her journey with her psychiatrist as they attempt to fuse her multiple identities into one through therapy and treatment. The book offers an in-depth look at Dissociative Identity Disorder, its causes, manifestations, and treatment.