The novel tells the story of a disillusioned American musicologist who leaves his life in New York City to embark on a journey to an untouched, primitive part of the Amazon jungle in South America. He is in search of ancient musical instruments. Along the way, he experiences a spiritual and philosophical transformation as he reconnects with nature and the primal roots of humanity. He also falls in love with a native woman, further deepening his connection to the land and its people.

Set in the Venezuelan llano, the book tells the story of an ongoing struggle between two powerful landowners. One is Doña Bárbara, a ruthless and cunning woman who has used her cunning and seductive prowess to amass a large amount of land. The other is Santos Luzardo, an educated city-dweller who returns to the plains to reclaim his family's property. The novel explores themes of civilization versus barbarism, the struggle for land, and the magical realism of the South American landscape.

"Eva Luna" is a magical realism novel that tells the story of the eponymous protagonist, an orphaned girl in a South American country who uses her gift of storytelling to navigate through life. As she grows, she becomes a servant, a lover, and a revolutionary, always using her stories to bring comfort, provoke thought, and incite change. The narrative is a rich tapestry of characters, politics, and history, all woven together with a touch of the fantastical.