Set in the 12th century, the novel follows Baudolino, a self-proclaimed liar and adventurer, as he travels from his home in Italy to the mythical kingdom of Prester John. Along the way, he becomes embroiled in a series of political and religious intrigues, meets a variety of fantastical creatures, and tells a series of increasingly elaborate lies. The narrative is framed as a story Baudolino is telling to a Byzantine historian, adding another layer of unreliability to his already questionable narrative.

This novel intertwines two parallel narratives, one set in the 13th century and one in the modern day. The contemporary story follows a discontented American housewife who, while working as a reader for a literary agency, comes across a novel about the 13th-century poet Rumi and his spiritual mentor, Shams of Tabriz. As she delves into their story, she uncovers Shams' forty rules of love and begins to question her own life and relationships. The historical narrative, on the other hand, explores the transformative friendship between Rumi and Shams, and how their bond revolutionized Rumi's poetry and outlook on life.

This novel delves into the obsessive love of Kemal, a wealthy Istanbulite, for Füsun, a distant relative and a shopgirl, which begins in 1975 and spans over 30 years. After a brief affair, Füsun marries another man, but Kemal's love remains unyielding. He starts collecting objects that remind him of his love for her, eventually creating a museum dedicated to their relationship. Set against the backdrop of Istanbul's changing society, the story explores themes of love, longing, class, and the power of memory, as Kemal's life becomes a testament to his unattainable desire, encapsulated within the walls of his museum.

The novel centers around a father's profound journey as he navigates the complexities of raising a son with cerebral palsy. The narrative delves into the emotional and social challenges they face, exploring themes of acceptance, resilience, and the redefinition of fatherhood. Through his son's condition, the father confronts his own vulnerabilities and the societal prejudices against disability, ultimately experiencing a profound transformation that leads him to a deeper understanding of love, identity, and the human experience.